Blar i forfatter "Ekblad, Nicklas"
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Melt processability of amorphous solid dispersions during hot-melt extrusion. Screening using vacuum compression moulding and evaluation by rheology and solid-state analysis
Ekblad, Nicklas (Master thesis; Mastergradsoppgave, 2018-05-15)Soluplus is a suitable excipient for innovative manufacturing techniques such as hot-melt extrusion (HME). While Soluplus is useful for forming amorphous solid dispersions (ASD’s) during HME, the resulting extrudates are often stiff and brittle. In order to achieve suitable dosage forms, with optimal downstream processability, an efficient screening for suitable formulations is required. Vacuum ...